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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11528 | H100 | Others | |
H100 is a Cl- transport inhibitor, no effect against KCl cotransporter. It has partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger. | |||
T22831 | Protein kinase inhibitor H-7 dihydrochloride | H-7 dihydrochloride | PKC |
Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor. Protein kinase inhibitor H-7 dihydrochloride (100 μM) significantly inhibits TPA (skin tumor promoter, 12-O-... | |||
T19561 | Simetryn | Others | |
Simetryn is a rice paddy herbicide and acts as a chemical stressor retarding tadpole growth and development without disrupting thyroid functions, even at 1/100 of the 96-h LC50 value. | |||
TN1018 | Angeloylgomisin H | PPAR | |
Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines. | |||
T11463 | GR 103691 | Dopamine Receptor | |
GR 103691 is a potent, selective dopamine D3 receptor antagonist (Ki: 0.4 nM). It shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites. | |||
T2700 | FTI-277 hydrochloride | FTI 277 HCl | Apoptosis , Transferase , Ras |
FTI-277 hydrochloride (FTI 277 HCl) is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I. | |||
T37816 | SB 243213 | ||
SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range o... | |||
T35868 | BCAT-IN-2 | ||
BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be u... | |||
T38050 | CP-609754 | Transferase | |
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n... | |||
T35610 | 2,5-dimethyl Celecoxib | Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor | |
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... | |||
TN2415 | Mudanpioside H | Antibacterial | |
Mudanpioside H is a peony from the root bark of Paeonia lactiflora with a broad spectrum of antimicrobial activity and MIC values ranging from 100 to 500 microg/mL. | |||
T11864 | Iptacopan | LNP023 | Others |
Iptacopan (LNP023) is an inhibitor with high affinity for factor B. | |||
T79519 | YXG-158 | Androgen Receptor | |
YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1.28 μM and CYP17A1 inhibition with an IC50 of 100 nM. It is ... | |||
T68765 | Spirorenone | ||
Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I... | |||
T38327 | Cryogenine | ||
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity.1 It inhibits prostaglandin synthetase (IC50 = 424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the... | |||
T38350 | TAS 205 | ||
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS ... | |||
T72897 | P-CAB agent 2 | ||
P-CAB Agent 2 is a potent, orally active potassium-competitive acid blocker (P-CAB) and gastric acid secretion inhibitor that effectively inhibits H+/K+-ATPase activity, showing an IC50 value of <100 nM. It also demonstr... | |||
T72181 | P-CAB agent 2 hydrochloride | ||
P-CAB agent 2 hydrochloride is a potent, orally active potassium-competitive acid blocker (P-CAB) and gastric acid secretion inhibitor. It effectively inhibits H+/K+-ATPase activity, with an IC50 value of <100 nM, and ta... | |||
T38160 | STING Agonist 1a | ||
STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expres... | |||
TN3549 | Burchellin | Antifection | |
Burchellin has larvicidal activity, it can interfer with the development cycle of the mosquito, where its strongest toxic effect is 100% mortality in larvae (L3) at concentrations ¥ 30 ppm. Burchellin and licarin A have... |